Lisse Group - Research

Regenerative biology of growth factors

The functional role of neurotrophic growth factors as it relates to cutaneous tissue repair and regeneration remains obscure. The Lisse Group is interested in how glial cell line-derived neurotrophic factor (GDNF) promotes skin and hair follicle regeneration after injury and disease. We utilize a combination of approaches to study the effects of GDNF including lineage tracing, conditional cell type-specific gene knockout mouse models, single cell sequencing and mass spectrometry in order to identify and study targeted cells, genes and proteins.

Vitamin D and tissue regeneration and function

How vitamin D affects tissue regeneration is unclear. The Lisse Group is interested in how vitamin D can affect tissue systems to modulate the regenerative and repair processes, namely within organ systems such as skin. We utilize a number of approaches ranging from cell type-specific knockout mouse models to chromatin immunoprecipitation sequencing assays to study the role of vitamin D and its receptor interactions. The ultimate goal is to be able to tailor the tissue regenerative process by modulating the vitamin D signaling pathway.

Collagen and tissue regeneration

Collagen is the major extracellular matrix (ECM) protein in the body, and defects in its functions result in debilitating human disorders associated with impaired tissue regeneration. Through lessons learned from the vitamin D and growth factor signaling pathways, the Lisse Group is interested in better understanding how collagens are regulated in order to help develop therapeutic approaches to diseases such as Osteogenesis Imperfecta – a condition associated with impaired ECM proteins.

The Lisse Lab is recruiting talented graduate students interested in various facets of biology. Please contact Dr. Lisse for further information.